摘要目的 探讨赖氨葡锌颗粒联合西咪替丁对轮状病毒肠炎患儿血清肌酸激酶同工酶(CK-MB)、天冬氨酸氨基转移酶(AST)、白细胞介素(IL)-6水平变化及预后的影响.方法 选取81例轮状病毒肠炎患儿,按随机数字表法分组,对照组40例予以西咪替丁治疗,观察组41例予以西咪替丁+赖氨葡锌颗粒治疗,观察比较两组临床治疗效果、脱水纠正时间、止泻时间、退热时间及血清CK-MB、AST、IL-6水平变化情况,并统计两组不良反应发生情况及活力、生理功能、精神状况评分.结果 观察组治疗总有效率为95.12%(39/41),对照组为75.00%(30/40),两组治疗总有效率比较差异有统计学意义(P<0.05).观察组脱水纠正时间、退热时间及止泻时间均短于对照组,差异有统计学意义(P<0.05);观察组治疗后血清CK-MB、AST及IL-6水平均低于对照组,差异有统计学意义(P<0.01);观察组不良反应发生率为17.07%(7/41),对照组为10.00%(4/40),两组不良反应发生率比较差异无统计学意义(P>0.05).观察组治疗后生理功能、活力及精神状况评分均高于对照组,差异有统计学意义(P<0.01).结论 赖氨葡锌颗粒与西咪替丁联合治疗轮状病毒肠炎效果显著,安全性高,可缓解炎性反应,改善患儿心肌酶谱各指标水平及生命质量.

abstractsObjective To investigate the effects of lysine and gluconic acid zinc granules combined with cimetidine on serum creatine kinase isoenzyme (CK-MB), aspartate aminotransferase (AST) and interleukin-6 (IL-6) levels and prognosis in children with rotavirus enteritis. Methods Eighty-one children with rotavirus enteritis were randomly divided into control group (40 patients) and observation group (41 patients).The patients in control group were treated with cimetidine, and those in the observation group were treated with cimetidine combined with lysine and gluconic acid zinc granules. Clinical treatment, dehydration correction time, diarrhea time, fever time and serum CK-MB, AST and IL-6 levels were observed and compared between two groups. The occurrence of toxic side effects and vitality, physiological function, mental status scores were statistically analyzed. Results The total effective rate in observation group was 95.12%(39/41), in control group was 75.00%(30/40), and there was significant difference (P < 0.05). The dehydration correction time, diarrhea time, fever time after treatment in observation group was less than that in control group (P<0.05). The serum CK-MB, AST and IL-6 levels after treatment in observation group were significantly lower than those in control group (P<0.01). There was no significant difference in the incidence of side effects between observation group 17.07%(7/41) and control group 10.00%(4/40) (P>0.05). The scores of physiological function, vitality and mental status scores in observation group were higher those in control group, and there were significant differences(P < 0.01). Conclusions The lysine and gluconic acid zinc granules combined with cimetidine in the treatment of rotavirus enteritis gets has a significant effect and high safety, which can alleviate the inflammatory reaction and improve the myocardial enzymes levels and the quality of life.