摘要目的:观察沙库巴曲缬沙坦治疗青年扩张型心肌病（DCM）对左心室收缩活动同步性影响。方法:选取2017年7月至2018年7月广东医科大学附属医院49例左心室收缩失同步性扩张型心肌病患者，随机分为两组，试验组使用沙库巴曲缬沙坦治疗，对照组使用洛汀新治疗，疗程12个月。二维彩超检测左心室舒张末期内径（LVEDd）、左心室收缩末期内径（LVESd）、射血分数（EF），三维彩超检测左心室舒张末期容积（LVEDV）、左心室收缩末期容积（LVESV）、EF、16节段的收缩期失同步指数（SDI）变化，检测治疗前后血浆N末端B型利钠肽原（NT-proBNP）浓度。结果:三维彩超发现治疗12个月后，试验组LVEDV较对照组明显减少[（180.5 ± 42.7）ml比（160.5 ± 45.6 ml）]，差异有统计学意义（P<0.05）。试验组左心室16节段收缩失同步性（SDI）显著改善，与对照组相比，显著减低[（8.2 ± 3.6）%比（10.8 ± 4.1）%]（P<0.05）。治疗12个月后血浆NT-proBNP试验组与对照组相比，下降更加明显[（105.54 ± 13.25）ng/L比（137.27 ± 14.36）ng/L]，差异有统计学意义（P<0.05）。结论:沙库巴曲缬沙坦能有效改善青年DCM患者左心室收缩失同步性。

abstractsObjective:To investigate the effect of sakubatril/valsartan on left ventricular systolic dyssynchrony in young patients with dilated cardiomyopathy (DCM).Methods:Forty-nine patients with left ventricular systolic asynchronism DCM from July 2017 to July 2018 in Guangdong Medical University Affiliated Hospital were randomly divided into two groups. The experimental group was treated with sakubatra valsartan and the control group was treated with lotensin for 12 months. Left ventricular end-diastolic diameter (LVEDd), left ventricular end-systolic diameter (LVESd) and ejection fraction (EF) were measured by two-dimensional color Doppler echocardiography. The left ventricular end-diastolic volume (LVEDV), left ventricular end-systolic volume (LVESV), ejection fraction (EF) and systolic dyssynchrony index (SDI) of 16 segments were measured by three-dimensional color Doppler ultrasound. Plasma NT-proBNP was tested before and after treatment.Results:After treated for 12 months, three-dimensional color Doppler ultrasonography showed the LVEDV in the experimental group decreased significantly: (180.5 ± 42.7) ml vs. (160.5 ± 45.6) ml, P<0.05. The left ventricular systolic asynchronism (SDI) of 16 segments in the experimental group significantly improved, and the value of left ventricular SDI significantly decreased compared with that of the control group: (8.2 ± 3.6)% vs. (10.8 ± 4.1)%, P<0.05. Plasma NT-proBNP decreased more significantly in the experimental group compared with that in the control group: (105.54 ± 13.25) ng/L vs. (137.27 ± 14.36) ng/L, P<0.05. Conclusions:Sakubatril/valsartan can effectively improve left ventricular systolic dyssynchrony in young patients with dilated cardiomyopathy.