摘要目的:探讨外周血糖类抗原125（CA125）和N端脑钠肽前体（NT-proBNP）水平对慢性心力衰竭患者再住院率的预测价值。方法:选择浙江省嘉善县中医医院2018年1月至2019年6月收治的慢性心力衰竭患者135例作为观察组，按照纽约心脏病协会（NYHA）心功能分级标准分为Ⅱ级51例、Ⅲ级36例和Ⅳ级48例；另选择同期健康体检者80例作为对照组。采用酶联免疫法测定入选者CA125水平，采用免疫荧光法测定NT-proBNP水平。比较观察组和对照组　血清CA125和NT-proBNP水平变化，及不同心功能分级的慢性心力衰竭患者血清CA125和　NT-proBNP水平变化；随访6个月，观察不同CA125和NT-proBNP水平患者再住院率和病死率的差异。结果:观察组血清CA125和NT-proBNP水平高于对照组[（87.81 ± 23.51） kU/L比　（15.24 ± 3.24） kU/L、（397.25 ± 72.15） ng/L比（30.54 ± 3.41） ng/L]，差异均有统计学意义（ P<0.05）。心力衰竭患者随心功能分级的升高，血清CA125和NT-proBNP水平逐渐升高。不同CA125和NT-proBNP水平患者病死率比较差异无统计学意义（ P>0.05）。CA125 ≥ 35 kU/L的患者再住院率高于CA125<35 kU/L患者[64.00%（48/75）比41.67%（25/60）]，NT-proBNP ≥ 450 ng/L患者再住院率高于NT-proBNP<450 ng/L患者[65.57%（40/61）比44.59%（33/74）]，差异均有统计学意义（ P<0.05）。 结论:外周血CA125和NT-proBNP水平在慢性心力衰竭患者中明显升高，且与心功能分级密切相关，并对患者再住院具有重要预测价值。

abstractsObjective:To explore the predictive value of the levels of carbohydrate antigen125 (CA125) and N-terminal pro brain natriuretic peptide (NT-proBNP) in patients with chronic heart failure.Methods:One hundred and thirty-five patients with chronic heart failure admitted to Jiashan Hospital of Traditional Chinese Medicine from January 2018 to June 2019 were selected as the observation group. According to NYHA classification standard of cardiac function, 51 patients was Ⅱ grade, 36 patients was Ⅲ grade and 48 patients was Ⅳ grade. Eighty healthy people in same period were selected as the control group. The levels of CA125 and NT-proBNP were measured by enzyme-linked immunosorbent assay and immunofluorescence respectively. The levels of serum CA125 and NT-proBNP were compared between the two groups, and the mortality and readmission of the patients with different levels of CA125 and NT-proBNP were observed after 6 months of follow-up.Results:The serum CA125 and NT-proBNP levels in the observation group were higher than those in the control group [(87.81 ± 23.51) kU/L vs. (15.24 ± 3.24) kU/L, (397.25 ± 72.15) ng/L vs. (30.54 ± 3.41) ng/L] , and there were significant differences ( P<0.05). The levels of serum CA125 and NT-proBNP gradually increased with the NYHA classification. There was no significant difference in mortality between patients with different CA125 and NT-proBNP levels ( P>0.05). The readmission rate of CA125 ≥ 35 kU/L was higher than that of CA125<35 kU/L [64.00% (48/75) vs. 41.67%(25/60)] , the readmission rate of patients with NT-proBNP ≥ 450 ng/L was higher than that of patients with NT-proBNP<450 ng/L [65.57%(40/61) vs. 44.59%(33/74)], and there were significant differences ( P<0.05). Conclusions:The levels of CA125 and NT-proBNP in the peripheral blood of patients with chronic heart failure are significantly increased, which are closely related to the classification of cardiac function, and have an important predictive value for the readmission of patients.