摘要目的:探讨氟比洛芬酯和帕瑞昔布钠在无痛病房中肱骨干骨折患者术后镇痛效果的比较分析。方法:回顾性收集2017年1月至2019年9月解放军总医院第四医学中心住院治疗的200例肱骨干骨折患者，对使用氟比洛芬酯组（100例）和帕瑞昔布钠组（100例）两种镇痛药物的患者药效进行比较分析。结果:术后3 d两组患者视觉模拟评分法（VAS）评分较术前均显著降低[（4.26±0.96）分比（6.09±1.38）分、（4.04±1.19）分比（6.04±1.11）分]，差异有统计学意义（ P<0.01）；术后两组间比较差异无统计学意义（ P>0.05）。术后两组均有不同程度的不良反应（37例比17例），其中氟比洛芬酯组出现了较为明显的胃肠道不良反应（22例比3例），差异有统计学意义（ P<0.05）。术后帕瑞昔布钠组患者睡眠无影响较多（20例比8例）。两组患者对住院期间疼痛护理以满意为主。 结论:无痛病房中两种镇痛药物用于肱骨干骨折术后患者均能取得明显的镇痛效果；氟比洛芬酯组患者胃肠道不良反应及睡眠困扰情况均高于帕瑞昔布钠组。良好的疼痛控制会提高患者治疗的满意度。

abstractsObjective:To compare postoperative analgesic effect of flurbiprofen axetil and parecoxib sodium in patients with humeral shaft fracture in painless ward.Methods:All of 200 hospitalized humeral fractures patients were retrospectively studied in the painless ward of the Forth Medical Center of PLA General Hospital from January 2017 to September 2019 , the clinical effects of flurbiprofen axetil and parecoxib were compared.Results:Postoperative visual analogue scale (VAS) scores after 3 d of two groups of patients were significantly lower, compared with preoperative results: (4.26±0.96) scores vs. (6.09±1.38) scores, (4.04±1.19) scores vs. (6.04±1.11) scores, and the differences were statistical significantly ( P<0.01). Postoperative VAS score after 3 d of two groups had no statistical significance ( P>0.05). Two groups had different degree of adverse reactions after operation, and flurbiprofen axetil group had singnificant gastrointestinal adverse reaction: 22 patients vs. 3 patients( P<0.05). The number of patients in the parecoxib group were more than that in the flubiprofen axetil group without troubled sleep: 20 patients vs. 8 patients. Two groups of patients were satisfied with the pain care during hospitalization. Conclusions:Two analgestic drugs can obtain obvious analgesic effect in the treatment of bones surgery. The side effects and sleep disturbance in the flurbiprofen axetil group are higher than those in the parecoxib group. Good pain control can improve patients satisfaction with pain care.