摘要目的:探讨血管性血友病因子裂解酶（ADAMTS-13）、血小板平均容积与血小板计数比值（MPV/P）和凝集蛋白-1（ITLN-1）与急性心肌梗死患者经皮冠状动脉介入治疗（PCI）术后心肌梗死溶栓治疗临床试验（TIMI）血流分级的相关性及预测术后主要心血管不良事件（MACE）的价值。方法:选取2019年1月至2021年1月岳池县人民医院收治的126例行PCI的急性心肌梗死患者，根据术后3个月是否发生MACE分为MACE组（25例）和无MACE组（101例）。比较两组ADAMTS-13、MPV/P、ITLN-1水平，并分析其与术后TIMI血流分级的相关性及预测术后MACE的价值。结果:MACE组ADAMTS-13、ITLN-1水平低于无MACE组[（132.59 ± 43.05） μg/L比（186.33 ± 58.17） μg/L、（255.36 ± 80.24） mg/L比（342.65 ± 91.18） mg/L]，MPV/P水平高于无MACE组[（0.06 ± 0.02） fl/（ × 10 9/L）比（0.04 ± 0.01） fl/（ × 10 9/L）]，差异均有统计学意义（ P<0.05）。Spearman相关分析结果表明，ADAMTS-13、ITLN-1与TIMI血流分级呈正相关（ r = 0.692、0.622， P<0.01），MPV/P与TIMI血流分级呈负相关（ r = - 0.665， P<0.01）。ADAMTS-13、MPV/P联合ITLN-1预测MACE的曲线下面积为0.872。 结论:ADAMTS-13、MPV/P和ITLN-1与急性心肌梗死患者PCI术后血流分级和MACE发生有关，联合检测可作为预测MACE的可靠方案。

abstractsObjective:To investigate the relationship of von Willebrand factor cleaving enzyme(ADAMTS-13), ratio of mean platelet volume to platelet count (MPV/P), intelectin-1 (ITLN-1) and thrombolysis in myocardial infarction (TIMI) blood flow classification in acute myocardial infarction patients who performed percutaneous coronary intervention(PCI) and the value of predicting postoperative major cardiovascular adverse events (MACE).Methods:A total of 126 patients with acute myocardial infarction treated with PCI in Yuechi County People′s Hospital from January 2019 to January 2021 were selected and divided into MACE group (25 cases) and no MACE group (101 cases) according of the prognosis. The levels of ADAMTS-13, MPV/P and ITLN-1 were compared between the two groups, the correlation of above index and TIMI blood flow classification and the value of predicting postoperative MACE were analyzed.Results:The levels of ADAMTS-13 and ITLN-1 in the MACE group were lower than those in the MACE group, and the level of MPV/P was higher than that in the MACE group: (132.59 ± 43.05) μg/L vs. (186.33 ± 58.17) μg/L, (255.36 ± 80.24) mg/L vs. (342.65 ± 91.18) mg/L, (0.06 ± 0.02) fl/( × 10 9/L) vs. (0.04 ± 0.01) fl/( ×10 9/L), there were statistical differences ( P<0.05). The results of Spearman correlation analysis showed that the levels of ADAMTS-13 and ITLN-1 were positively correlated with TIMI blood flow classification ( r = 0.692, 0.622, P<0.01) , the level of MPV/P was negatively correlated with TIMI blood flow classification ( r = -0.665, P<0.01). The area under the curve of ADAMTS-13, MPV/P combined with ITLN-1 in protecting the MACE was 0.872. Conclusions:ADAMTS-13, MPV/P and ITLN-1 are related to the TIMI blood flow classification and MACE in patients with acute myocardial infarction after PCI, and the combined detection can be used as a reliable predictor of MACE.