摘要目的:探究内镜下幽门括约肌切开术（G-POEM）治疗胃轻瘫的有效性及安全性。方法:回顾性分析2022年5月至2023年9月在解放军总医院第一医学中心治疗行G-POEM的胃轻瘫患者的临床资料，术前均完成核素闪烁成像、超声造影胃排空检查、胃轻瘫问卷症状指数（GCSI）评分。主要观察指标为术后1、3、6和12个月的GCSI评分，分析患者术后临床改善、技术成功率和手术并发症。结果:共纳入10例胃轻瘫患者，其中特发性1例，合并糖尿病9例，合并焦虑症4例。G-POEM的技术成功率为10/10，未出现穿孔、出血等不良事件。术后患者GCSI平均分明显下降（ P<0.05）。临床成功率为7/10，术后复发率为1/10。 结论:G-POEM是一种安全、有效的内镜下治疗胃轻瘫的超级微创手术，但其长期的有效性仍需进一步探究。

abstractsObjective:To investigate the effectiveness and safety of gastric peroral endoscopic pyloromyotomy (G-POEM) in the treatment of gastroparesis.Methods:The clinical data of the patients who treated in the First Medical Center of Chinese PLA General Hospital from May 2022 to September 2023 were retrospectively analyzed. All the patients were perfected with gastric emptying scintigraphy, ultrasonographic gastric emptying examination, gastroparesis cardinal symptom index (GCSI) score. The main observation indexes were GCSI scores at 1, 3, 6 and 12 months after the treatment.Results:A total of 10 patients with gastroparesis were included, including 1 patient of idiopathic, 9 patients combined diabetes mellitus, and 4 patients combined anxiety disorders. The technical success rate of G-POEM was 10/10, and there were no adverse events such as perforation and bleeding. The mean GCSI score of the patients decreased significantly after the operation ( P<0.05). The clinical success rate was 7/10, and the postoperative recurrence rate was 1/10. Conclusions:G-POEM is a safe and effective super-minimally invasive procedure for the endoscopic treatment of gastroparesis, and its long-term effectiveness still needs to be further explored.