摘要Objective: To investigate morphological and biochemical mechanism between plant and drought stress by the way of plant survival under drought stress. Methods: Drought stress was imposed by irrigation daily (Control), 4, 7, 10 and 13 days interval (4 DID, 7 DID, 10 DID and 13 DID). Later they were irrigated at regular intervals for different maturity stage of Setaria italica (S. italica) (30 DAS, 50 DAS and 70 DAS). Results: The results showed the root length and compatible solutes were increased in all treatments when compared to control at the different age of plant maturity. The shoot length and chlorophyll pigment reduced in all treatments when compared to control at increasing plant maturity. Conclusions: This study suggestes the reduced shoot length, photosynthetic pigments of chlorophyll and increased root length, compatible solute accumulations made to drought tolerant adaptative mechanism.