摘要1例23岁男性因急性胃炎静脉滴注盐酸甲氧氯普胺注射液10 mg,滴注约5 min时,患者突然出现紧张恐惧、躁动不安、静坐不能、四肢肌肉痉挛、肢端皮肤发绀、面色甲床苍白、呼吸困难等症状,血压161/80 mmHg(1 mmHg=0.133 kPa),心率101次/min.立即给予吸氧(10 L/min),肌内注射地塞米松5 mg、苯海拉明25 mg,静脉滴注地塞米松5mg+0.9%氯化钠注射液500 ml.约1 h后,患者躁动、恐惧、四肢肌肉痉挛及皮肤发绀等症状好转,但仍有呕吐,给予奥美拉唑40 mg加入0.9%氯化钠注射液500 ml静脉滴注.3 h后,患者呕吐和精神神经症状消失.

abstractsA 23-year-old man with acute gastritis received an IV infusion of metoclopramide hydrochloride 10 mg. About 5 minutes after metoclopramide hydrochloride infusion started,he developed stress and fear,restlessness,akathisia,muscle spasm in extremities,cyanosis of limb skin,pale complexion and pale nail bed,and breathing difficulties. His blood pressure was 161/80 mmHg and heart rate was 101 beats/min. Oxygen inhalation at 10 L/min,intramuscular injections of dexamethasone 5 mg and diphenhy-dramine 25 mg and an IV infusion of dexamethasone 5 mg dissolved in 0.9% sodium chloride 500 ml were given. About one hour later,his restlessness,fear,muscle spasm and cyanosis gradually improved. Because of vomiting,an IV infusion of omeprazole 40 mg and 0.9% sodium chloride 500 ml was given. The vomiting and neuropsychiatric symptoms disappeared 3 hours later.