摘要1例44岁女性慢性肾脏病(5期)腹膜透析患者因感染性心内膜炎,给予注射用万古霉素500 mg静脉滴注、1次/12 h.第3次给药前发现用药频次不适宜,遂停用万古霉素,并于第2次用药后12 h采血检测万古霉素血药浓度,结果为＞50 mg/L.行持续腹膜透析24d后,万古霉素血药浓度降至9 mg/L,期间未见患者发生明显万古霉素相关不良反应.

abstractsA 44-year-old female patient with chronic kidney disease (stage 5) undergoing peritoneal dialysis received an Ⅳ infusion of vancomycin 500 mg once per 12 hours for infective endocarditis.Vancomycin was discontinued before the third administration for its frequency of administration was found inappropriate.The blood concentration of vancomycin was higher than 50 mg/L at 12 hours after the second dose.The blood concentration of vancomycin dropped to 9.2 mg/L after drug withdrawal and persistent peritoneal dialysis for 24 days.No other obvious adverse reactions related to vancomycin during this period.