摘要目的:探讨缩短静脉用药调配中心（PIVAS）配制和送达细胞毒性抗肿瘤药物时间的方法，使患者能够按说明书的要求及时用药。方法:组织项目团队调查2018年10月8日至12月31日北京天坛医院PIVAS配制的细胞毒性抗肿瘤药物配送时间延长的发生情况，分析其原因并进行改进；对改进后药物配送时间进行统计并与改进前进行比较，评价改进效果。结果:2018年10月8日至12月31日，我院PIVAS共配送细胞毒性抗肿瘤药物4 156袋，其中951袋药物需关注其配送时间。尽管记录时间不准确，但可以肯定至少有4.7%袋（45/951）药物配送时间延长。自2020年1月20日起，采取细胞毒性抗肿瘤药物处方优先审核，药物优先配制、专人专送的改进措施后，药物配送时间从以前的2.5~4.5 h缩短至0.5~4.0 h，配送时间延长的发生率下降到0.9%（12/1 281）。结论:医院PIVAS配送细胞毒性抗肿瘤药物存在药品配送时间延长的现象，可能导致液体放置时间超过说明书要求。细胞毒性抗肿瘤药物处方优先审核、配送可有效缩短药品的配送时间。

abstractsObjective:To explore a method to shorten the time for preparation and delivery of cytotoxic antineoplastic drugs in pharmacy intravenous admixture services (PIVAS), so that patients can use drugs in time according to the drug labels.Methods:The circumstances of prolonged preparation and delivery time of cytotoxic antineoplastic drugs prepared in PIVAS in Beijing Tiantan Hospital from October 8 to December 31, 2018 were investigated by the project team, the causes were analyzed, and the improvement strategies were made. The drug preparation and delivery time after the improvement strategies was counted and compared with that before improvement to evaluate the improvement effect.Results:From 8 October to 31 December 2018, a total of 4 156 bags of cytotoxic antineoplastic drugs were prepared and delivered in PIVAS in our hospital and the delivery time of 951 bags need to be paid attention to. Though the recording time was not accurate, it could be determined that the delivery time of at least 4.7% (45/951) of those bags had been extended. After taking the improvement measures of priority review for prescription of cytotoxic antineoplastic drugs, priority preparation, and delivery by special person from 20 January 2020, the delivery time of drugs was shortened from 2.5-4.5 hours to 0.5-4.0 hours, and the incidence of delivery time prolongation decreased to 0.9% (12/1 281).Conclusions:In hospital PIVAS, there was a phenomenon of delivery time prolongation of cytotoxic antineoplastic drugs when the drugs were delivered, which might lead to the storage time of the liquid exceeding the requirements of the drug labels. Priority prescription review and delivery of cytotoxic antineoplastic drugs could effectively shorten the delivery time.