摘要1例早产男婴出生20 h，持续无尿，全身水肿，血清肌酐238 μmol/L，肌酐清除率19.45 ml/min，胱抑素C 5.05 mg/L，血清白蛋白28.8 g/L，β 2微球蛋白6.52 mg/L，尿微量白蛋白120.2 mg/L，诊断为急性肾衰竭和低蛋白血症。其母亲在婴儿出生前因误诊口服沙库巴曲缬沙坦钠片（50 mg、2次/d）、布美他尼片（1 mg、1次/d）、硫酸氢氯吡格雷片（75 mg、1次/d）和匹伐他汀钙片（2 mg、1次/d）治疗9 d。考虑患儿急性肾衰竭和低蛋白血症与孕晚期沙库巴曲缬沙坦宫内暴露有关。给予静脉补充白蛋白、呋塞米和多巴胺等对症治疗。出生56 h后尿量增加，5 d后尿量恢复正常，8 d后肾功能基本恢复正常。

abstractsA preterm male infant suffered from continuous anuria for 20 hours, with systemic edema, serum creatinine 238 μmol/L, creatinine clearance rate 19.45 ml/min, cystatin C 5.05 mg/L, serum albumin 28.8 g/L, β 2 microglobulin 6.52 mg/L, and urinary microalbumin 120.2 mg/L. He was diagnosed with acute kidney failure and hypoalbuminemia. Before his birth, his mother had been treated with sacubitril valsartan sodium tablets (50 mg, twice daily), bumetanide tablets (1 mg, once daily), clopidogrel hydrogen sulfate tablets (75 mg, once daily) and pitavastatin calcium tablets (2 mg, once daily) for 9 days due to misdiagnose. The acute kidney failure and hypoalbuminemia was considered to be associated with in utero exposure to sacubitril valsartan in the third trimester, and symptomatic and supportive treatments such as intravenous albumin supplementation, furosemide, and dopamine were given. After 56 hours of birth, his urine volume obviously increased; after 5 days, his urine volume returned to normal; after 8 days, his renal function basically returned to normal.