摘要药物不良反应（ADR）是临床诊疗中的重要问题，与ADR相关的基础研究至关重要。通过基础研究探讨ADR的发生机制，能够为制定有效的ADR预防策略和针对性治疗方案提供理论依据；许多临床用药过程中发现的安全性问题可以通过基础研究得到有效验证和解决，如药物的量-效（毒）关系及药物相互作用等；药物毒性相关的基础研究是药物研发过程中不可或缺的关键环节，其研究成果直接关系到候选化合物的安全性和临床应用的可行性。目前，国内ADR相关基础研究的文献数量较少，希望更多研究者关注ADR和药物安全相关的基础研究，推动该领域向更高水平发展。

abstractsAdverse drug reaction (ADR) is an important problem in clinical diagnosis and treatment, and basic research related to ADR is essential. Exploring the mechanism of ADR through basic research can provide a theoretical basis for formulating effective prevention strategies and targeted treatment programs for ADR; many safety problems found in the process of clinical medication can be effectively verified and solved through basic research, such as the dose-response (toxicity) relationship of drugs and drug interactions; basic research related to drug toxicity is an indispensable key link in the process of drug research and development, and its research results are directly related to the safety of candidate compounds and the feasibility of clinical application. At present, there is a limited amount of literature on the basic research related to the mechanism of ADR in China. It is hoped that more researchers will pay attention to basic research related to ADR and drug safety, and promote the development of this field to a higher level.