换一批
换一批摘要The present study was aimed at the comparison of the pharmacokinetics of pure chlorogenic acid and extract of Solanum lyratum Thunb. The animals were allocated to two groups, and were administered chlorogenic acid or extract of S. lyratum Thunb. at a dose of 50.0 mg/kg orally. Blood samples were collected up to 8 h post-dosing. Plasma chlorogenic acid analyses were performed using an HPLC method with UV detector. The pharmacokinetic parameters were evaluated using non-compartmental assessment. Significant differences existed in the two groups for AUC0-t, AUC0-∞ and CLz/F. The reliable HPLC method was successfully applied to the determination of chlorogenic acid in rat plasma at dosage of 50.0 mg/kg.
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分类号
R965
栏目名称
ORIGINAL ARTICLE
DOI
10.1016/j.jpha.2011.09.006
发布时间
2012-07-13
基金项目
The study was supported by the Science and Technology Bureau of Liaoning Province
the Shenyang Technology Bureau
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