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3D biofabrication of vascular networks for tissue regeneration: A report on recent advances

摘要Rapid progress in tissue engineering research in past decades has opened up vast possibilities to tackle the challenges of generating tissues or organs that mimic native structures. The success of tissue en-gineered constructs largely depends on the incorporation of a stable vascular network that eventually anastomoses with the host vasculature to support the various biological functions of embedded cells. In recent years, significant progress has been achieved with respect to extrusion, laser, micro-molding, and electrospinning-based techniques that allow the fabrication of any geometry in a layer-by-layer fashion. Moreover, decellularized matrix, self-assembled structures, and cell sheets have been explored to replace the biopolymers needed for scaffold fabrication. While the techniques have evolved to create specific tissues or organs with outstanding geometric precision, formation of interconnected, functional, and perfused vascular networks remains a challenge. This article briefly reviews recent progress in 3D fab-rication approaches used to fabricate vascular networks with incorporated cells, angiogenic factors, proteins, and/or peptides. The influence of the fabricated network on blood vessel formation, and the various features, merits, and shortcomings of the various fabrication techniques are discussed and summarized.

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作者单位 Division of Biomedical Engineering, College of Engineering, University of Saskatchewan, Saskatoon, SK, Canada [1] Department of Mechanical Engineering, College of Engineering, University of Saskatchewan, Saskatoon, SK, Canada [2] Division of Biomedical Engineering, College of Engineering, University of Saskatchewan, Saskatoon, SK, Canada;Department of Mechanical Engineering, College of Engineering, University of Saskatchewan, Saskatoon, SK, Canada [3]
栏目名称 Review Paper
发布时间 2018-11-22
基金项目
This work was financially supported by the Natural Sciences and Engineering Research Council of Canada
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药物分析学报(英文)

药物分析学报(英文)

2018年8卷5期

277-296页

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