Single-cell RNA-sequencing and subcellular spatial transcriptomics facilitate the translation of liver microphysiological systems for regulatory application

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摘要Reducing the use of animal models in drug development and safety assessment has long been supported by the U.S.Food and Drug Administration(FDA).The report by Royal Society for the Pre-vention of Cruelty to Animals indicates that in 2020,experiments involved the use of over 100 million animals,with the United States leading the list by utilizing 20 million animals.Beyond ethical con-siderations associated with animal testing and the costs in terms of time and money,animal models are not always effective in predict-ing human reactions to drug exposure.

作者 Dan Li ^[1] Zhou Fang ^[2] Qiang Shi ^[3] Nicholas Zhang ^[4] Binsheng Gong ^[1] Weida Tong ^[1] Ahmet F.Coskun ^[5] Joshua Xu ^[1] 学术成果认领

作者单位 Division of Bioinformatics and Biostatistics,National Center for Toxicological Research,U.S.Food and Drug Administration,Jefferson,AR,72079,USA ^[1] Wallace H.Coulter Department of Biomedical Engineering,Georgia Institute of Technology and Emory University,Atlanta,GA,30332,USA;Machine Learning Graduate Program,Georgia Institute of Technology,Atlanta,GA,30332,USA ^[2] Division of Systems Biology,National Center for Toxicological Research,U.S.Food and Drug Administration,Jefferson,AR,72079,USA ^[3] Wallace H.Coulter Department of Biomedical Engineering,Georgia Institute of Technology and Emory University,Atlanta,GA,30332,USA;Interdisciplinary Bioengineering Graduate Program,Georgia Institute of Technology,Atlanta,GA,30332,USA ^[4] Wallace H.Coulter Department of Biomedical Engineering,Georgia Institute of Technology and Emory University,Atlanta,GA,30332,USA;Interdisciplinary Bioengineering Graduate Program,Georgia Institute of Technology,Atlanta,GA,30332,USA;Parker H.Petit Institute for Bioengineering and Bioscience,Georgia Institute of Technology,Atlanta,GA,30332,USA ^[5]

栏目名称 Perspective

DOI 10.1016/j.jpha.2023.06.013

发布时间 2023-11-13

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