Neuroinflammation attenuation effects by celastrol and PDIA3 in the amygdala,hippocampus and dorsal raphe nucleus of obese mice
摘要Nowadays,roughly 603.7 million people are bothered by obesity[1].More seriously,obesity brings inflammation to the peripheral and central nervous system,which compromises the comorbidity of obesity,major depression[2],and cognitive deficits[3].Drug competent in the comorbidity is still lacking.In 2015,Liu et al.[4]reported celastrol(CEL)as a powerful anti-obesity agent.In our previous study,CEL were proved effective in treating obesity mice comorbid with depression and cognitive deficits(COM).
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