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Shenqi Fuzheng injection alleviates chemotherapy-induced cachexia by restoring glucocorticoid signaling in hypothalamus

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摘要Chemotherapy-induced cachexia(CIC)is a debilitating condi-tion characterized by weight loss,muscle atrophy,and anorexia[1].While peripheral mechanisms of cachexia have been extensively studied,the involvement of the central nervous system(CNS)in CIC is often overlooked.Chemotherapeutic drugs cause stress re-sponses and inflammation,which may impact the hypothalamus and disrupt systemic energy and neuroendocrine functions.Un-derstanding hypothalamic roles in regulating these processes can provide insights into CIC's mechanisms and aid in developing novel therapies.Shenqi Fuzheng injection(SQ),a Chinese proprietary medicine,has shown therapeutic effects in alleviating chemotherapy-related cytotoxicity and neurological symptoms[2].

作者 Entezar Berik ^[1] Zijia Zhang ^[2] Wei Li ^[2] Yawen Liu ^[2] Sihan Chen ^[2] Wenyong Wu ^[3] Zhaojun Wang ^[2] Xinqin Kong ^[2] Wenqiang Pei ^[3] Huiqing Dong ^[3] Huali Long ^[2] Min Lei ^[2] Jennifer Yiyang Wang ^[4] Liangfeng Liu ^[5] Jinjun Hou ^[2] Jing Feng ^[6] Zhaoxia Li ^[7] Wanying Wu ^[2] De-an Guo ^[2] 学术成果认领

作者单位 Beijing Key Lab of TCM Collateral Disease Theory Research,School of Traditional Chinese Medicine,Capital Medical University,Beijing,100069,China;National Engineering Research Center of TCM Standardization Technology,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai,201203,China ^[1] National Engineering Research Center of TCM Standardization Technology,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai,201203,China;University of Chinese Academy of Sciences,Beijing,100049,China ^[2] National Engineering Research Center of TCM Standardization Technology,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai,201203,China;School of Chinese Materia Medica,Nanjing University of Chinese Medicine,Nanjing,210029,China ^[3] National Engineering Research Center of TCM Standardization Technology,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai,201203,China ^[4] Limin Pharmaceutical Factory,Livzon Group Limited,Shaoguan,Guangdong,512028,China;Guangdong Corporate Key Laboratory of High-End Liquid Medicine R&D,Industrilization,Shaoguan,Guangdong,512028,China ^[5] University of Chinese Academy of Sciences,Beijing,100049,China;Center for Neurological and Psychiatric Research and Drug Discovery,Shanghai Institute of Materia Medica,Chinese Academy of Science,Shanghai,201203,China ^[6] Beijing Key Lab of TCM Collateral Disease Theory Research,School of Traditional Chinese Medicine,Capital Medical University,Beijing,100069,China ^[7]

栏目名称

Short Communications

DOI 10.1016/j.jpha.2023.08.015

发布时间 2024-06-26（万方平台首次上网日期，不代表论文的发表时间）

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