换一批摘要Glioblastoma(GBM)is a primary and fatal subtype of adult brain tumors.Despite standard treatments,including surgical resection and temozolomide(TMZ)chemotherapy,overall survival is only 16 months[1].Profound genomic heterogeneity and altered tran-scriptional profiles drive chemoresistance,leading to tumor recurrence and a poor prognosis.Gain of chromosome 7 is a pivotal event in initiation and recurrence[2].Our previous studies high-lighted that engrailed 2(EN2),a homeobox transcription factor at 7q363,is negatively correlated with glioma malignancy[3].
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DOI
10.1016/j.jpha.2023.12.002
发布时间
2024-12-17（万方平台首次上网日期，不代表论文的发表时间）
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