摘要Since June 2020,the re-emergence of coronavirus disease 2019(COVID-19)epidemics in parts of China was linked to the cold chain,which attracted extensive attention and heated discussions from the public.According to the typical characteristics of these epidemics,we speculated a possible route of transmission from cold chain to human.A series of factors in the supply chain contributed to the epi-demics if the cold chain were contaminated by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),such as temperature,humidity,personal hygiene/protection,and disinfection.The workers who worked in the cold chain at the receiving end faced a higher risk of being infected when they were not well protected.Facing the difficult situation,China put forward targeted and powerful countermeasures to block the cold chain-related risk.However,in the context of the unstable pandemic situation globally,the risk of the cold chain needs to be recognized and evaluated seriously.Hence,in this review,we reviewed the cold chain-related epidemics in China,analyzed the possible mechanisms,introduced the Chinese experience,and suggested coping strategies for the global epidemic prevention and control.