Highlights of the 2nd International Symposium on Tribbles and Diseases: tribbles tremble in therapeutics for immunity, metabolism, fundamental cell biology and cancer

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摘要The Tribbles (TRIB) family of pseudokinase proteins has been shown to play key roles in cell cycle,metabolic diseases,chronic inflammatory disease,and cancer development.A better understanding of the mechanisms of TRIB pseudokinases could provide new insights for disease development and help promote TRIB proteins as novel therapeutic targets for drug discovery.At the 2nd International Symposium on Tribbles and Diseases held on May 7-9,2018 in Beijing,China,a group of leading Tribbles scientists reported their findings and ongoing studies about the effects of the different TRIB proteins in the areas of immunity,metabolism,fundamental cell biology and cancer.Here,we summarize important and insightful overviews from 4 keynote lectures,13 plenary lectures and 8 short talks that took place during this meeting.These findings may offer new insights for the understanding of the roles of TRIB pseudokinases in the development of various diseases.

作者单位 State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China ^[1] Department of Biochemistry, Institute of Integrative Biology, University of Liverpool, Liverpool L69 7ZB, UK ^[2] Division of Molecular Biology and Biochemistry, School of Biological Sciences, University of Missouri-Kansas City, Kansas City, MO 64110, USA ^[3] School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore;Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 639798, Singapore;Institute of Molecular and Cell Biology, Singapore 138673, Singapore;KK Women's and Children Hospital, Singapore 229899, Singapore ^[4] Biochemistry Department, School of Biomedical Sciences, University of Otago, Dunedin 9054, New Zealand ^[5] Centre for Biomedical Research(CBMR), University of Algarve, Campus de Gambelas, Faro 8005-139, Portugal;Department of Biomedical Sciences and Medicine, University of Algarve, Faro 8005-139, Portugal;Algarve Biomedical Center(ABC), University of Algarve, Campus de Gambelas, Faro 8005-139, Portugal ^[6] Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield S10 2RX, UK ^[7] Paul O'Gorman Leukaemia Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow, Scotland G61 1QH, UK ^[8] Division of Carcinogenesis, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo 135-8550, Japan ^[9] Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA ^[10] Centre de Recherche en Transplantation et Immunologie(ou CRTI), Inserm, Université de Nantes, Nantes, France, CHU Nantes, Nantes,France;Institut de Transplantation Urologie Néphrologie(ou ITUN), CHU Nantes, Nantes, France ^[11] CIC bioGUNE, Bizkaia 48160, Spain;CIBERONC, Madrid 28029, Spain;Ikerbasque, Basque Foundation for Science, Bilbao 48080, Spain;Biochemistry and Molecular Biology Department, University of the Basque Country(UPV/EHU), Bilbao 48080, Spain ^[12] Institute for Diabetes and Cancer IDC, Helmholtz Center Munich, Neuherberg 85764, Germany;Joint Heidelberg-IDC Translational Diabetes Program, University Hospital Heidelberg, Heidelberg 85764, Germany;Molecular Metabolic Control, Medical Faculty, Technical University Munich, Munich 85764, Germany;German Center for Diabetes Research(DZD), Neuherberg 85764, Germany ^[13] Division of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA ^[14] School of Sport and Health Sciences, Cardiff Metropolitan University, Cardiff CF5 2YB, UK ^[15] Centre for Endocrinology, William Harvey Research Institute, John Vane Science Centre, Queen Mary, University of London, London EC1M 6BQ, UK ^[16] Intelligent Pharma-Mind the Byte S.L., Barcelona 08028, Spain;Facultat de Farmàcia, Universitat de Barcelona, Barcelona 08028, Spain ^[17] Section of Neurobiology, Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA ^[18] State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050, China ^[19] Department of Biochemistry and Molecular Biolgy, School of Biology, Complutense University and Instituto de Investigaciones Sanitarias San Carlos(IdISSC), Madrid 28040, Spain ^[20] Department of Biochemistry and Molecular Biology, Institute of Neurosciences, Faculty of Medicine, Universitat Autonoma de Barcelona, Bellaterra 08193, Spain ^[21]