Mechanism of allosteric activation of SIRT6 revealed by the action of rationally designed activators

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作者 Shaoyong Lu ^[1] Yingyi Chen ^[2] Jiacheng Wei ^[2] Mingzhu Zhao ^[3] Duan Ni ^[4] Xinheng He ^[2] Jian Zhang ^[1] 学术成果认领

作者单位 Department of Pathophysiology,Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education,Shanghai Jiao Tong University,School of Medicine,Shanghai 200025,China;State Key Laboratory of Oncogenes and Related Genes,Renji Hospital,Shanghai Jiao Tong University,School of Medicine,Shanghai 200127,China ^[1] Department of Pathophysiology,Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education,Shanghai Jiao Tong University,School of Medicine,Shanghai 200025,China ^[2] State Key Laboratory of Oncogenes and Related Genes,Renji Hospital,Shanghai Jiao Tong University,School of Medicine,Shanghai 200127,China ^[3] The Charles Perkins Centre,University of Sydney,Sydney NSW 2006,Australia ^[4]

关键词 Allosteric driver Allosteric sites Allosteric mechanisms Drug design Enzyme catalysis Protein dynamics

栏目名称 Short communication

发布时间 2021-07-01

基金项目

This work was supported in part by grants from the National Natural Science Foundation of China China Postdoctoral Science Foundation the Innovation Program of Shanghai Municipal Education Commission the Shanghai Science and Technology Innovation and the Shanghai Health and Family Planning System Excellent Subject Leader and Excellent Young Medical Talents Training Program

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药学学报（英文版）

2021年11卷5期

1355-1361页

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Mechanism of allosteric activation of SIRT6 revealed by the action of rationally designed activators

药学学报（英文版）

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药学学报（英文版）

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Mechanism of allosteric activation of SIRT6 revealed by the action of rationally designed activators

药学学报（英文版）

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药学学报（英文版）

相关期刊

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