换一批摘要Amorphous solid dispersions(ASDs)are popular for enhancing the solubility and bioavailability of poorly water-soluble drugs.Various approaches have been employed to produce ASDs and novel tech-niques are emerging.This review provides an updated overview of manufacturing techniques for preparing ASDs.As physical stability is a critical quality attribute for ASD,the impact of formulation,equipment,and process variables,together with the downstream processing on physical stability of ASDs have been dis-cussed.Selection strategies are proposed to identify suitable manufacturing methods,which may aid in the development of ASDs with satisfactory physical stability.
更多相关知识
关键词
Amorphous solid dispersionsStabilityDrug deliveryManufacturingSolvent evaporationMelting processCo-precipitationDownstream processingSelection criteria
栏目名称
发布时间
2021-11-23（万方平台首次上网日期，不代表论文的发表时间）
- 浏览2
- 被引0
- 下载0
相似文献
- 中文期刊
- 外文期刊
- 学位论文
- 会议论文
