Salmonella flagella confer anti-tumor immunological effect via activating Flagellin/TLR5 signalling within tumor microenvironment

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作者 Jianxiang Chen ^[1] Yiting Qiao ^[2] Guo Chen ^[3] Cunjie Chang ^[4] Heng Dong ^[4] Bo Tang ^[5] Xiawei Cheng ^[3] Xiufeng Liu ^[3] Zichun Hua ^[6] 学术成果认领

作者单位 School of Life Sciences,Nanjing University,Nanjing 210023,China;College of Pharmacy,School of Medicine,Hangzhou Normal University,Hangzhou 311100,China;Department of Hepatology,the Affiliated Hospital of Hangzhou Normal University,Hangzhou Normal University,Hangzhou 311121,China ^[1] School of Life Sciences,Nanjing University,Nanjing 210023,China;Division of Hepatobiliary and Pancreatic Surgery,Department of Surgery,the First Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou 310003,China ^[2] School of Life Sciences,Nanjing University,Nanjing 210023,China ^[3] College of Pharmacy,School of Medicine,Hangzhou Normal University,Hangzhou 311100,China ^[4] Changzhou High-Tech Research Institute of Nanjing University and Jiangsu TargetPharma Laboratories Inc.,Changzhou 213164,China ^[5] School of Life Sciences,Nanjing University,Nanjing 210023,China;Changzhou High-Tech Research Institute of Nanjing University and Jiangsu TargetPharma Laboratories Inc.,Changzhou 213164,China;School of Biopharmacy,China Pharmaceutical University,Nanjing 211198,China ^[6]

关键词 Bacteria-mediated cancer therapy Salmonella VNP20009 Flagellum Flagellin TLR5 NF-κB Cancer immune therapy

栏目名称 Original articles

发布时间 2021-12-16

基金项目

This study was supported by grants from the Jiangsu Provincial Nature Science Foundation National Natural Science Foundation of China Zhejiang Provincial Natural Science Foundation of China for Distinguished Young Scholars We thank Dr Wenhui Jiang for her assistance for the immunohistochemical staining during the ex-periments and thank Dr Dongping Wei for his encouragement on the setup of this project We are grateful to the mice for their contributions to this study

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药学学报（英文版）

2021年11卷10期

3165-3177页

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Salmonella flagella confer anti-tumor immunological effect via activating Flagellin/TLR5 signalling within tumor microenvironment

药学学报（英文版）

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药学学报（英文版）

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Salmonella flagella confer anti-tumor immunological effect via activating Flagellin/TLR5 signalling within tumor microenvironment

药学学报（英文版）

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药学学报（英文版）

相关期刊

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