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Inhaled heparin polysaccharide nanodecoy against SARS-CoV-2 and variants

摘要To the Editor:As of January 27,2022,there were 363,062,293 cases and 5,645,884 deaths from the COVID-19 pandemic1.The prevalent mutated strains have aggravated the global pandemic2.SARS-CoV-2 is highly mutable,and the mutations on the spike(S)protein resulted in a high transmission of COVID-19 and vaccine breakthrough infection3.For example,there is a notable decrease in neutralizing ability of BNT162b2 vaccination-elicited antibodies against the Delta and other variants4,5,and attenuation of peak viral burden and vaccine effectiveness are reduced with Delta variant6.

作者 Bin Tu ^[1] Huiyuan Wang ^[2] Xinran An ^[3] Jingkun Qu ^[4] Qianqian Li ^[5] Yanrong Gao ^[1] Mingjie Shi ^[2] Hong Qiu ^[2] Yongzhuo Huang ^[6] 学术成果认领

作者单位 State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China;University of Chinese Academy of Sciences,Beijing 100049,China ^[1] State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China ^[2] State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China;University of Michigan College of Pharmacy,Ann Arbor,MI 48109,USA ^[3] State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China;School of Chinese Materia Medica,Nanjing University of Chinese Medicine,Nanjing 210023,China ^[4] State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China;Nanchang University College of Pharmacy,Nanchang 330006,China ^[5] State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China;University of Chinese Academy of Sciences,Beijing 100049,China;Zhongshan Institute for Drug Discovery,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Zhongshan 528437,China;NMPA Key Laboratory for Quality Research and Evaluation of Pharmaceutical Excipients,Shanghai 201203,China;Taizhou University,School of Advanced Study,Institute of Natural Medicine and Health Product,Taizhou 318000,China ^[6]

关键词 SARS-CoV-2 Delta variant Heparan sulfate Spike protein Heparin nanoparticle Pulmonary delivery

栏目名称

Letter to the editor

发布时间 2022-10-19（万方平台首次上网日期，不代表论文的发表时间）

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准确一般字义偏差语意偏离译文作用小提交