摘要Nano-drug delivery strategies have been highlighted in cancer treatment,and much effort has been made in the optimization of bioavailability,biocompatibility,pharmacokinetics profiles,and in vivo distributions of anticancer nano-drug delivery systems.However,problems still exist in the delicate bal-ance between improved anticancer efficacy and reduced toxicity to normal tissues,and opportunities arise along with the development of smart stimuli-responsive delivery strategies.By on-demand responsiveness towards exogenous or endogenous stimulus,these smart delivery systems hold promise for advanced tumor-specificity as well as controllable release behavior in a spatial-temporal manner.Meanwhile,the blossom of nanotechnology,material sciences,and biomedical sciences has shed light on the diverse modern drug delivery systems with smart characteristics,versatile functions,and modification possibil-ities.This review summarizes the current progress in various strategies for smart drug delivery systems against malignancies and introduces the representative endogenous and exogenous stimuli-responsive smart delivery systems.It may provide references for researchers in the fields of drug delivery,biomate-rials,and nanotechnology.