摘要Ebola virus(EBOV)infection leads to staggeringly high mortality rate.Effective and low-cost treatments are urgently needed to control frequent EBOV outbreaks in Africa.In this study,we report that a natural compound called berbamine hydrochloride strongly inhibits EBOV replication in vitro and in vivo.Our work further showed that berbamine hydrochloride acts by directly binding to the cleaved EBOV glyco-protein(GPcl),disrupting GPcl interaction with viral receptor Niemann-Pick Cl,thus blocking the fusion of viral and cellular membranes.Our data support the probability of developing anti-EBOV small molecule drugs by targeting viral GPcl.More importantly,since berbamine hydrochloride has been used in clinic to treat leukopenia,it holds great promise of being quickly repurposed as an anti-EBOV drug.
作者单位Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences and Peking Union Medical School,Beijing 100050,China[1]CAS Key Laboratory of Pathogenic Microbiology and Immunology,Institute of Microbiology,Chinese Academy of Sciences,Beijing 100101,China[2]CAS Key Laboratory of Pathogenic Microbiology and Immunology,Institute of Microbiology,Chinese Academy of Sciences,Beijing 100101,China;University of Chinese Academy of Sciences,Beijing 100049,China[3]Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences and Peking Union Medical School,Beijing 100050,China;CAMS Key Laboratory of Antiviral Drug Research,Institute of Medicinal Biotechnology,Peking Union Medical College,Chinese Academy of Medical Sciences,Beijing 100050,China[4]
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