换一批
换一批7-(4-氯苄基)-7,8,13,13a-四氢小檗碱在家兔体内的代谢产物分析
ANALYSIS OF THE METABOLITE OF 7-(4-CHLORBENZYL)-7,8,13,13a-TETRAHYDROBERBERINE IN RABBIT
摘要AIM To explore the biotransformation of compound 7-(4-chlorbenzyl)-7,8,13,13a-tetrahydroberberine in the rabbit. METHODS Analyze the rabbit bile sample with HPLC, LC/MS and LC/NMR. RESULTS A metabolite and unchanged 7-(4-chlorbenzyl)-7,8,13,13a-tetrahydroberberine were found in the rabit bile, the metabolite was characterized and its structure was elucidated. CONCLUSION Compound 7-(4-chlorbenzyl)-7,8,13,13a-tetrahydroberberine is metabolized by demethylation at 10-OCH3 position.
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栏目名称
研究论文
DOI
10.3321/j.issn:0513-4870.2001.02.016
发布时间
2004-01-08
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