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Asprecosides A-J,ten new pentacyclic triterpenoid glycosides with cytotoxic activity from the roots of Ilex asprella

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学术成果认领

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摘要Phytochemical study of the n-BuOH extract of Ilex asprella resulted in the discovery often new pentacyclic trit-erpenoid glycosides,comprising nine ursane-type glycosides(1-9)and one oleanane-type glycoside(10),along with seven known compounds(11-17).Compound 1 is the first reported 19,22-epoxy ursane triterpenoid glycoside,whereas 4 and 5 are rare examples of ursane triterpenoid glycosides containing a 28,19-lactone group.The structural characterization of these compounds was achieved using spectroscopic and chemical techniques,as well as single-crystal X-ray analysis.Compounds 7,12,15,and 17 exhibited moderate cytotoxic activities against H1975 and HCC827 cancer cells.

作者 Yuwei Wu ^[1] Baihui Zhang ^[1] Wenxian Li ^[2] Lihua Peng ^[3] Weilin Qiao ^[3] Wei Li ^[1] De-an Guo ^[1] 学术成果认领

作者单位 School of Pharmaceutical Sciences,Southern Medical University,Guang-zhou 510515,People's Republic of China;Zhongshan Institute for Drug Discovery,Shanghai Institute of Materia Medica,Chinese Academy of Sci-ences,Zhongshan 528400,People's Republic of China ^[1] Zhongshan Institute for Drug Discovery,Shanghai Institute of Materia Medica,Chinese Academy of Sci-ences,Zhongshan 528400,People's Republic of China ^[2] Zhongshan Zhongzhi Pharmaceutical Group Co.Ltd.,Zhongshan 528400,People's Republic of China ^[3]

关键词 Ilex asprella Pentacyclic triterpenoid glycoside Ursane Oleanane Cytotoxic activity

DOI 10.1007/s13659-025-00499-7

发布时间 2025-06-10（万方平台首次上网日期，不代表论文的发表时间）

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