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Marine natural products as a source of novel anticancer drugs:an updated review(2019-2023)

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摘要Marine natural products have long been recognized as a vast and diverse source of bioactive compounds with poten-tial therapeutic applications,particularly in oncology.This review provides an updated overview of the significant advances made in the discovery and development of marine-derived anticancer drugs between 2019 and 2023.With a focus on recent research findings,the review explores the rich biodiversity of marine organisms,including sponges,corals,algae,and microorganisms,which have yielded numerous compounds exhibiting promising anticancer prop-erties.Emphasizing the multifaceted mechanisms of action,the review discusses the molecular targets and pathways targeted by these compounds,such as cell cycle regulation,apoptosis induction,angiogenesis inhibition,and modu-lation of signaling pathways.Additionally,the review highlights the innovative strategies employed in the isola-tion,structural elucidation,and chemical modification of marine natural products to enhance their potency,selectivity,and pharmacological properties.Furthermore,it addresses the challenges and opportunities associated with the development of marine-derived anticancer drugs,including issues related to supply,sustainability,synthesis,and clinical translation.Finally,the review underscores the immense potential of marine natural products as a valuable reservoir of novel anticancer agents and advocates for continued exploration and exploitation of the marine environ-ment to address the unmet medical needs in cancer therapy.

作者 Hesham R.El-Seedi ^[1] Mohamed S.Refaey ^[2] Nizar Elias ^[3] Mohamed F.El-Mallah ^[4] Faisal M.K.Albaqami ^[5] Ismail Dergaa ^[6] Ming Du ^[7] Mohamed F.Salem ^[8] Haroon Elrasheid Tahir ^[9] Maria Dagliaa ^[10] Nermeen Yosri ^[11] Hongcheng Zhang ^[12] Awg H.El-Seedi ^[13] Zhiming Guo ^[14] Shaden A.M.Khalifa ^[15] 学术成果认领

作者单位 Department of Chemistry,Faculty of Science,Islamic University of Madinah,42351 Madinah,Saudi Arabia;International Research Center for Food Nutri-tion and Safety,Jiangsu University,Zhenjiang 212013,China;International Joint Research Laboratory of Intelligent Agriculture and Agri-Products Pro-cessing,Jiangsu Education Department,Jiangsu University,Nanjing 210024,China;Department of Chemistry,Faculty of Science,Menoufia University,Shebin El-Kom 31100107,Egypt ^[1] Department of Pharmacognosy,Faculty of Pharmacy,University of Sadat City,Sadat City 32897,Egypt ^[2] Department of Laboratory Medicine,Faculty of Medicine,University of Kalamoon,P.O.Box 222,Dayr Atiyah,Syria ^[3] Department of Chemistry,Faculty of Science,Menoufia University,Shebin El-Kom 31100107,Egypt ^[4] Biology Department,Faculty of Science,Islamic University of Madinah,42351 Madinah,Saudi Arabia ^[5] Primary Health Care Corporation(PHCC),Doha,Qatar ^[6] School of Food Science and Technology,National Engineering Research Center of Seafood,Dalian Polytechnic Univer-sity,Dalian 116034,China ^[7] Department of Environmental Biotechnology,Genetic Engineering and Biotechnology Research Institute,GEBRI,University of Sadat City,P.O.Box:79,Sadat City,Egypt ^[8] Agricultural Product Process-ing and Storage Lab,School of Food and Biological Engineering,Jiangsu University,Zhenjiang 212013,Jiangsu,China ^[9] International Research Center for Food Nutri-tion and Safety,Jiangsu University,Zhenjiang 212013,China;Department of Pharmacy,University of Napoli Federico Ⅱ,Via D.Montesano 49,80131 Naples,NA,Italy ^[10] School of Food and Biological Engineering,Jiangsu University,Zhenji-ang 212013,China;Chemistry Department of Medicinal and Aromatic Plants,Research Institute of Medicinal and Aromatic Plants(RIMAP),Beni-Suef University,Beni-Suef 62514,Egypt ^[11] State Key Laboratory of Resource Insects,Institute of Apicultural Research,Chinese Academy of Agricultural Sciences,Beijing 100093,China ^[12] International IT College of Sweden Stockholm,Arena Academy,H?lsobrunnsgatan 6,11361 Stockholm,Sweden ^[13] School of Food and Biological Engineering,Jiangsu University,Zhenji-ang 212013,China ^[14] International Research Center for Food Nutri-tion and Safety,Jiangsu University,Zhenjiang 212013,China;Psychiatry and Neurology Department,Capio Saint G?ran's Hospital,Sankt G?ransplan 1,112 19 Stockholm,Sweden ^[15]

关键词 Marine natural products Microorganism Anticancer Clinical trials Drugs

DOI 10.1007/s13659-024-00493-5

发布时间 2025-06-10（万方平台首次上网日期，不代表论文的发表时间）

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