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Structurally diverse polyketides and alkaloids produced by a plant-derived fungus Penicillium canescens L1

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学术成果认领

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摘要A series of structurally diverse polyketides(1-3),sesterterpenoids(24 and 25),and alkaloids(26-34)were isolated from the fermentation of a plant-derived fungus Penicillium canescens L1 on solid rice medium.Among these second-ary metabolites,penicanesols A-G(1-7)were new structures,which were elucidated by NMR,HR-ESI-MS,ECD calcula-tion,and X-ray diffraction.Penicanesol A(1)represented a rare dimer derived from phthalan derivatives,characterized by a 5/6/6/6/5 heteropentacyclic core.The bioassay on the NCI-H1975 cell model showed that two compounds had good cytotoxic activities,and the most significant activate compound 13 had an IC50 value of 4.24±0.13 μM,more than the posi-tive control drug(12.99±0.13 μM).

作者 Wei-Ye Wu ^[1] Xun Wei ^[1] Qiong Liao ^[2] Yi-Fan Fu ^[1] Lei-Ming Wu ^[1] Lei Li ^[1] Shu-Qi Wu ^[1] Qing-Ren Lu ^[1] Fang-Yu Yuan ^[1] Dong Huang ^[1] Zhang-Hua Sun ^[3] Tao Yuan ^[4] Gui-Hua Tang ^[1] 学术成果认领

作者单位 School of Pharmaceutical Sciences,Sun Yat-sen University,Guang-zhou 510006,China ^[1] Laboratory Animal Center,Sun Yat-sen University,Guangzhou 510006,China ^[2] Guangdong Provincial Key Laboratory of Utiliza-tion and Conservation of Food and Medicinal Resources in Northern Region,Shaoguan University,Shaoguan 512005,China ^[3] The Laboratory of Effective Substances of Jiangxi Genuine Medicinal Materials,College of Life Sciences,Jiangxi Normal University,Nanchang 330022,China ^[4]

关键词 Endophytic fungus Penicillium canescens Polyketides Alkaloids Cytotoxic activity

DOI 10.1007/s13659-025-00503-0

发布时间 2025-10-11（万方平台首次上网日期，不代表论文的发表时间）

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