摘要The Meliaceae family,widely distributed in tropical and subtropical regions,has been traditionally used for medici-nal purposes,particularly in treating infections and inflammatory diseases.The objective of this study is to provide a comprehensive account of the nitrogen-containing secondary metabolites and their biological activities that have been isolated from the Meliaceae family between the years 1979 and 2024.Studies on nitrogen-containing com-pounds of the Meliaceae family were collected and analyzed using data from SciFinder,PubMed,Google Scholar,Scopus and World Flora Online.Over the course of more than four decades,numerous studies have been conducted on a variety of plant parts,including twigs,stems,barks,roots,fruits,seeds,and leaves.These studies have identified approximately 326 compounds belonging to diverse chemical groups,such as alkaloids,limonoids,triterpenoids,and nitrogen-containing flavaglines being the largest group of natural products,comprising 118 compounds(36.2％).Several compounds have been evaluated for insecticidal,anti-inflammatory,molluscicide,antibacterial,antimalarial,tyrosinase inhibition,osteoclast differentiation inhibition,and α-glucosidase inhibition activity.The systematic clas-sification and analysis of these compounds provide insights into their biosynthesis and bioactivities,paving the way for future drug development.