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Advancement in nanocarrier-mediated delivery of herbal bioactives:from bench to beside

摘要The resurgence of interest in traditional herbal remedies stems from an increasing appreciation for their complex phytochemical profiles and potential for synergistic therapeutic effects.However,the therapeutic potential of plant extracts is often limited by poor absorption and potential toxicity related to conventional delivery methods.This review explores the application of nanocarrier-mediated delivery systems,such as nanoparticles(NPs),liposomes,and nanoemulsions,to address these challenges.These biocompatible carriers offer enhanced stability and targeted delivery of herbal compounds,improving their efficacy and reducing unwanted side effects.By enabling precise distribution,nanotechnology optimizes the potency of herbal medicine across diverse applications,including regen-erative medicine,wound healing,anticancer,and infection treatment.This review provides a systematic description of successful applications of nano-delivery technologies,nanoparticles,liposomes,nanoemulsions,and hybrid carri-ers,for the targeted delivery of some well-characterized herbal bioactives(curcumin,allicin,berberine,resveratrol etc.)and the enhanced therapeutic performance of herbal bioactives across a variety of preclinical models.

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作者单位 Department of Chemical Engineering,Pennsylvania State University,Univer-sity Park,PA 16802-1503,USA [1] Faculty of Biology,Medicine and Health,Uni-versity of Manchester,Manchester,UK [2] Department of Biotechnology,School of Chemical Engineering,College of Engineering,University of Tehran,Tehran,Iran [3] School of Pharmacy,International Campus,Tehran University of Medical Sciences,Tehran,Iran [4] Department of Chemical and Petroleum Engineer-ing,Sharif University of Technology,Tehran,Iran [5] Department of Chemical Engineering,Isfahan University of Technology,Isfahan 84156-83111,Iran [6] Department of Biology,Faculty of Sciences,Arak University,Arak,Iran [7] Chemical Engineering Department,Oklahoma State University,Stillwater,OK,USA [8] Department of Tissue Engineering,School of Advanced Technologies in Medicine,Fasa University of Medical Sciences,Fasa 74615-168,Iran [9] Department of Chemistry,Faculty of Physics and Chemistry,Alzahra Uni-versity,Tehran,Iran [10] Department of Pharmaceutical Biotechnology,School of Pharmacy,Shiraz University of Medical Sciences,Shiraz 71348-14336,Iran;Pharmaceutical Sciences Research Center,Shiraz University of Medical Sciences,Shiraz 71348-14336,Iran [11] School of Natural Sciences,Faculty of Sci-ence and Engineering,Macquarie University,Sydney,NSW 2109,Australia [12] Universidade Federal Do Rio Grande(FURG),Instituto de Ciências Biológicas(ICB),Programa de Pós-Gradua??o Em Ciências Fisiológicas(PPGCF),Rio Grande,RS,Brazil;Universidad de Buenos Aires(UBA),CONICET,Instituto de Química y Metabolismo del Fármaco(IQUIMEFA),Facultad de Farmacia y Bioquímica,Buenos Aires,Argentina [13]
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DOI 10.1007/s13659-025-00550-7
发布时间 2026-04-27(万方平台首次上网日期,不代表论文的发表时间)
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