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Unilateral post-chemotherapy robot-assisted retroperitoneal lymph node dissection in Stage Ⅱ non-seminomatous germ cell tumor:A tertiary care experience

摘要Objective:Post-chemotherapy retroperitoneal lymph node dissection(PC-RPLND)represents an integral component of the management of patients with non-seminomatous germ cell tumor(NSGCT).Modified templates have been proposed to minimize the surgical morbidity of the procedure.Moreover,the implementation of robotic surgery in this setting has been explored.We report our experience with unilateral post-chemotherapy robot-as-sisted retroperitoneal lymph node dissection(PC-rRPLND)for clinical Stages ⅡA and ⅡB NSGCTs.Methods:A retrospective single institution review was performed including 33 patients under-going PC-rRPLND for Stages ⅡA and ⅡB NSGCTs between January 2015 and February 2019.Following orchiectomy,patients were scheduled for chemotherapy with three cycles of bleomycin-etoposide-cisplatin.Patients with a residual tumor of<5 cm and an ipsilateral metastatic disease on pre-and post-chemotherapy CT scans were eligible for a unilateral tem-plate in absence of rising tumor markers.Descriptive statistics were provided for demo-graphics,clinical characteristics,intraoperative and postoperative parameters.Perioperative,oncological,and functional outcomes were recorded.Results:Overall,7(21.2%)patients exhibited necrosis or fibrosis;14(42.4%)had mature tera-toma;and 12(36.4%)had viable tumor at final histology.The median lymph node size at surgery was 25(interquartile range[IQR]21-36)mm.Median operative time was 180(IQR 165-215)min and no major postoperative complications were observed.Anterograde ejacula-tion was preserved in 75.8%of patients.Median follow-up was 26(IQR 19-30)months and a total of three recurrences were recorded.Conclusion:PC-rRPLND is a reliable and technically reproducible procedure with safe oncolog-ical outcomes and acceptable postoperative ejaculatory function in well selected patients with NSGCTs.

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作者 Dario Franzese [1] Antonio Tufano [2] Alessandro Izzo [1] Raffaele Muscariello [1] Giovanni Grimaldi [1] Giuseppe Quarto [1] Luigi Castaldo [1] Sabrina Rossetti [1] Savio Domenico Pandolfo [3] Sonia Desicato [1] Paola Del Prete [4] Matteo Ferro [5] Sandro Pignata [6] Sisto Perdonà [1] 学术成果认领
作者单位 Department of Urology,National Cancer Institute,Pascale Foundation,Naples,Italy [1] Urology Unit,Department of Maternal-Child and Urological Sciences,"Sapienza"University,Rome,Italy [2] Department of Neurosciences,Science of Reproduction and Odontostomatology,University of Naples Federico Ⅱ,Naples,Italy [3] Scientific Directorate,Istituto Nazionale Tumori di Napoli,IRCCS"G.Pascale",Naples,Italy [4] Division of Urology,European Institute of Oncology(IEO),IRCCS,Milan,Italy [5] Division of Medical Oncology,Department of Uro-Gynaecological Oncology,Istituto Nazionale per lo Studio e la Cura dei Tumori"Fondazione G.Pascale",IRCCS,Naples,Italy [6]
DOI 10.1016/j.ajur.2023.05.002
发布时间 2024-03-12(万方平台首次上网日期,不代表论文的发表时间)
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