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Hydrogen sulfide responsive nanoplatforms:Novel gas responsive drug delivery carriers for biomedical applications

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学术成果认领

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摘要Hydrogen sulfide(H2S)is a toxic,essential gas used in various biological and physical processes and has been the subject of many targeted studies on its role as a new gas transmitter.These studies have mainly focused on the production and pharmacological side effects caused by H2S.Therefore,effective strategies to remove H2S has become a key research topic.Furthermore,the development of novel nanoplatforms has provided new tools for the targeted removal of H2S.This paper was performed to review the association between H2S and disease,related H2S inhibitory drugs,as well as H2S responsive nanoplatforms(HRNs).This review first analyzed the role of H2S in multiple tissues and conditions.Second,common drugs used to eliminate H2S,as well as their potential for combination with anticancer agents,were summarized.Not only the existing studies on HRNs,but also the inhibition H2S combined with different therapeutic methods were both sorted out in this review.Furthermore,this review provided in-depth analysis of the potential of HRNs about treatment or detection in detail.Finally,potential challenges of HRNs were proposed.This study demonstrates the excellent potential of HRNs for biomedical applications.

作者 Jiafeng Zou ^[1] Zeting Yuan ^[1] Xiaojie Chen ^[2] You Chen ^[1] Min Yao ^[1] Yang Chen ^[1] Xiang Li ^[1] Yi Chen ^[1] Wenxing Ding ^[1] Chuanhe Xia ^[1] Yuzheng Zhao ^[3] Feng Gao ^[4] 学术成果认领

作者单位 Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell Metabolism,School of Pharmacy,East China University of Science and Technology,Shanghai 200237,China ^[1] Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province,School of Pharmaceutical Sciences,Zhejiang Chinese Medical University,Hangzhou 310053,China ^[2] Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell Metabolism,School of Pharmacy,East China University of Science and Technology,Shanghai 200237,China;Shanghai Key Laboratory of New Drug Design,School of Pharmacy,East China University of Science and Technology,Shanghai 200237,China;Optogenetics and Synthetic Biology Interdisciplinary Research Center,State Key Laboratory of Bioreactor Engineering,East China University of Science and Technology,Shanghai 200237,China;CAS Center for Excellence in Brain Science,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai 200031,China;Research Unit of New Techniques for Live-cell Metabolic Imaging,Chinese Academy of Medical Sciences,Beijing 100050,China ^[3] Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell Metabolism,School of Pharmacy,East China University of Science and Technology,Shanghai 200237,China;Shanghai Key Laboratory of Functional Materials Chemistry,East China University of Science and Technology,Shanghai 200237,China;Shanghai Key Laboratory of New Drug Design,School of Pharmacy,East China University of Science and Technology,Shanghai 200237,China;Optogenetics and Synthetic Biology Interdisciplinary Research Center,State Key Laboratory of Bioreactor Engineering,East China University of Science and Technology,Shanghai 200237,China ^[4]

关键词 Hydrogen sulfide Disease mechanisms Removal of hydrogen sulfide Responsive nanoplatforms Challenges Biomedical applications

栏目名称

Review articles

DOI 10.1016/j.ajps.2023.100858

发布时间 2024-08-26（万方平台首次上网日期，不代表论文的发表时间）

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