摘要Objective:To study the chemical constituents from the aerial parts of Scoparia dulcis.Methods:Various chromatographic techniques were used to separate the constituents and their structures were elucidated using spectroscopic methods and by comparing their data to those reported in the litera-tures.The α-glucosidase inhibitory activity assay was used to identify potential α-glucosidase inhibitors.Results:Nine compounds were isolated from the aerial parts of S.dulcis.Their structures were identified as Scoparic zolone(1),(2S)-2,7-dihydroxy-2H-1,4-benzoxazin-3(4H)-one(2),(2R)-7-hydroxy-2H-1,4-benzoxazin-3(4H)-one-2-O-β-D-glucopyranoside(3),(2R)-7-methoxy-2H-1,4-benzoxazin-3(4H)-one-2-O-β-D-glucopyranoside(4),(2S)-7-hydroxy-2H-1,4-benzoxazin-3(4H)-one-2-O-β-D-glucopyranoside(5),6-methoxy-benzoxazolin-2(3H)-one(6),4-acetonyl-3,5-dimethoxy-p-quinol(7),zizyvoside I(8),and 3,4-dihydroxy benzeneacetic acid(9).Compound 2 showed the potent α-glucosidase inhibitory activity with an IC50 value of(132.8±11.5)μmol/L,which is 28-fold higher than the positive control acarbose.Conclusion:Compound 1 is a new natural product.Compounds 2 and 9 have not been reported in Scoparia before.Compounds 3,5,7,8 are isolated from Scrophulariaceae for the first time.