摘要The discovery and characterization of molecular targets from traditional Chinese medicine(TCM)repre-sents a paradigm shift in contemporary drug development.This approach systematically bridges empir-ical TCM knowledge with modern pharmacological principles,establishing a robust framework for rational drug design.Through integrative systems-chemical biology approaches,we can now mechanis-tically elucidate the therapeutic basis of TCM's bioactive properties,facilitating the accelerated identifi-cation of both novel molecular targets and conserved pharmacological pathways.This multidisciplinary strategy significantly enhances drug development efficiency while advancing therapeutic innovation to address critical unmet medical needs.With the rapid advancement of next-generation target deconvolu-tion technologies and AI-driven computational platforms,TCM is poised to make increasingly substantial contributions to modern pharmacotherapy.