摘要目的 研究地榆Sanguisorba officinalis水溶性化学成分.方法 采用大孔树脂(D101、HP-20)、透析袋、ToyopearlHW-40、反相硅胶RP18等柱色谱方法进行分离纯化,并运用1H-NMR、13C-NMR、ESI-MS等多种波谱方法对化合物进行结构鉴定.结果 从地榆10％乙醇部位中分离并鉴定了25个化合物,分别为4-(4'-hydroxyphenyl)-2-butanone-4'-O-β-D-glucopyranoside (1)、phenethanol-β-vicianoside (2) 、junipetrioloside A (3) 、citroside A (4) 、corchoionoside C (5) 、adenosine(6)、tryptophan (7)、tachinoside (8)、d-mandelic acid-β-D-glucopyranoside (9) 、(+)-(7S,8S)-guaiacylglycerol 8-O-β-D-glucopyranoside (10)、biophenol (11)、3,5-dihydroxyphenethyl alcohol 3-O-β-glucopyranoside (12) 、syringin (13) 、(2E,5E)-3,7-dimethyl-2,5-octadiene-1,7-diol (14)、(±)-3-hydroxy-3,7-dimethyloct-6-enoic acid (15)、(2Z)-2,6-dimethy1-2,7-octadiene-1,6-diol(16) 、phlorizin (17)、(+)-cyclo-olivil-6-O-β-D-glucopyranoside (18)、5'-methoxy-8'-hydroxyl-(+)-isolariciresinol-4'-O-β-D-glucopyranoside (19)、phenethyl-6-O-α-L-arabinofuranosyl-β-D-glucoside (20)、gaultherin (21)、benzyl-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside (22) 、(2E)-7-hydroxy-3,7-dimethyl-2-octenyl-6-O-α-arabinofuranosyl-β-D-glucopyranoside (23)、3,3',4'-tri-O-methylellagic acid (24)、methyl-4-(β-D-glucopyranosyloxy)-3-hydroxy-5-methoxybenzoate (25).结论 化合物1～22为首次从该植物中分离得到.