BINDING AND INTERACTION OF TRANSCRIPTIONAL REGULATOR HUMAN DAXX WITH ADENOVIRUS12 E1B 55 KILODALTON ONCOPROTEIN

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摘要Objective: To study the disruption of co- localization of human Daxx(hDaxx) with promyelocytic leukemia protein(PML) at the PML oncogenic domains (PODs) by the interaction of hDaxx with adenovirus(Ad) 12 E1B 55 Kilodalton Oncoprotein (Ad12 E1B 55kD). Methods: The direct binding reaction of hDaxx and Ad12 E1B 55kD was analyzed by coimmunoprecipitation and Western blotting in vivo or in vitro. The interaction of hDaxx with Ad12 E1B 55kD was studied using yeast two-hybrid assay. Results: hDaxx bounded directly to Ad12 E1B 55kD in vivo and in vitro. hDaxx interacted with full length Ad12 E1B 55kD. Conclusion: Transcriptional regulator hDaxx directly binds to and interacts with Ad12 E1B 55kD.

作者 万艳平 ^[1] 吴移谋 ^[1] 朱翠明 ^[1] 谭立志 ^[1] 余敏君 ^[1] 廖端芳 ^[2] 学术成果认领

作者单位 Department of Microbiology, Faculty of Medicine, Nanhua University, Hengyang,421001 ^[1] Department of Pharmacology, Faculty of Medicine, Nanhua University, Hengyang,421001 ^[2]

关键词 Human Daxx Ad12 E1B 55kD Binding Interaction

分类号 Q279

栏目名称 Original Articles

发布时间 2004-02-20

基金项目

grants from Ministry of Education of P.R.China

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中国癌症研究(英文版)

2003年15卷4期

273-276页

SCIMEDLINEISTICCSCDCA

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BINDING AND INTERACTION OF TRANSCRIPTIONAL REGULATOR HUMAN DAXX WITH ADENOVIRUS12 E1B 55 KILODALTON ONCOPROTEIN

中国癌症研究(英文版)

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中国癌症研究(英文版)

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BINDING AND INTERACTION OF TRANSCRIPTIONAL REGULATOR HUMAN DAXX WITH ADENOVIRUS12 E1B 55 KILODALTON ONCOPROTEIN

中国癌症研究(英文版)

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中国癌症研究(英文版)

相关期刊

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