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The emerging roles of retromer and sorting nexins in the life cycle of viruses

摘要Retromer and sorting nexins(SNXs)transport cargoes from endosomes to the trans-Golgi network or plasma membrane.Recent studies have unveiled the emerging roles for retromer and SNXs in the life cycle of viruses,including members of Coronaviridae,Flaviviridae and Retroviridae.Key components of retromer/SNXs,such as Vps35,Vps26,SNX5 and SNX27,can affect multiple steps of the viral life cycle,including facilitating the entry of viruses into cells,participating in viral replication,and promoting the assembly of virions.Here we present a comprehensive updated review on the interplay between retromer/SNXs and virus,which will shed mechanistic insights into controlling virus infection.

作者 Yue Lu ^[1] Ping He ^[2] Yuxuan Zhang ^[2] Yongwen Ren ^[1] Leiliang Zhang ^[1] 学术成果认领

作者单位 Department of Clinical Laboratory Medicine,The First Affiliated Hospital of Shandong First Medical University&Shandong Provincial Qianfoshan Hospital,Jinan,250013,China;Department of Pathogen Biology,School of Basic Medical Sciences,Shandong First Medical University&Shandong Academy of Medical Sciences,Jinan,250117,China;Medical Science and Technology Innovation Center,Shandong First Medical University&Shandong Academy of Medical Sciences,Jinan,250117,China ^[1] Department of Pathogen Biology,School of Basic Medical Sciences,Shandong First Medical University&Shandong Academy of Medical Sciences,Jinan,250117,China;Medical Science and Technology Innovation Center,Shandong First Medical University&Shandong Academy of Medical Sciences,Jinan,250117,China ^[2]

关键词 Retromer Coronaviridae Flaviviridae Retroviridae Sorting nexin(SNX)

栏目名称

REVIEW

发布时间 2022-09-14（万方平台首次上网日期，不代表论文的发表时间）

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