换一批长链非编码 RNA 对心脏发育的表观遗传学调控研究进展
Progress on epigenetic regulation of long noncoding RNAs in cardiac development and heart diseases
摘要It was previously revealed that noncoding RNAs, especially microRNAs, control cardiac genes and regulate heart function.Recently, growing evidence from high-throughput genomic platforms has confirmed that long non-coding RNAs ( lncRNAs) serve as new and enigmatic regulators in cardiac development and homeostasis.Nevertheless, lit-tle is known about their characteristics compared to microRNAs.Here, we review the latest progress on lncRNAs in cardiac biology and diseases, summarizing detailed knowledge of their functions and novel cardiac-related gene regulatory mecha-nisms in epigenetic processes.Finally, we highlight that lncRNAs could be promising therapeutic targets and diagnostic bi-omarkers in cardiac pathophysiology.
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分类号
R363（病理学）
栏目名称
DOI
10.3969/j.issn.1000-4718.2015.11.029
发布时间
2015-12-14（万方平台首次上网日期，不代表论文的发表时间）
基金项目
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- 被引2
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