换一批摘要Congenital heart disease is one of the main types of birth defect.The mammalian heart developmen-tal progress requires precise gene patterning in time and space.In addition to the gene sequence,recent research showed that the regulation of core cardiac gene expression has been proved to be closely related to cardiac transcription factors as well as the modification of genomic architecture of the histone.Methylation of histone might be the key nodes in the regula-tion of cardiac gene expression and chromatin structure.This review focuses on the role of histone H 3 methylation in heart development process,which may lay a foundation for the prediction of epigenetic modification of congenital heart disease.
更多相关知识
栏目名称
DOI
10.3969/j.issn.1000-4718.2018.05.029
发布时间
2018-06-13（万方平台首次上网日期，不代表论文的发表时间）
基金项目
- 浏览133
- 被引1
- 下载83
相似文献
- 中文期刊
- 外文期刊
- 学位论文
- 会议论文
