摘要目的 观察肾综合征出血热(HFRS)患者可溶性细胞间黏附分子(sICAM-1)的动态变化,探讨其在发病机制中的作用.方法 2006-2007年,在齐齐哈尔市财贸职工医院选择30例HFRS患者作为病例组,选择20例健康献血者为对照组,采集静脉血,采用双抗体夹心ELISA法检测血清sICAM-1的水平,并检测尿素氮水平.结果 HFRS患者血清sICAM-1水平在发病早期、极期、恢复期分别为(47.56±6.51)、(94.23±15.36)、(54.19±8.42)ng/L,尿素氮水平分别为(5.16±0.12)、(33.84±9.24)、(8.20±1.30)mmol/L;对照组sICAM-1水平为(22.63±3.40)ng/L,尿素氮水平为(4.20±0.56)mmol/L.上述两指标的任意两组组间比较,差异均有统计学意义(P均<0.01).结论 sICAM-1作为保护因素参与HFRS的发病,细胞免疫在HFRS发病机制中占有重要地位.

abstractsObjective To study the dynamic changes of soluble intracellular adhesion molecule-1 (sICAM-1), and to assess its role in the pathogenesis of hemorrhagic fever(HFRS) with renal syndrome. Methods A total of 30 patients with HFRS(case group) and 20 healthy subjects (control group) from Worker Hospital of Finance & Commerce of Qiqihar city were included in the study during 2006 - 2007. Double-antibody sandwich ELISA method was used to measure the level of sICAM-1 in serum samples. Results The serum levels of sICAM-1 in patients with HFRS in early stage, critical stage, convalescent stage were(47.56±6.51), (94.23±15.36), (54.19±8.42)ng/L,respectively. The serum level of sICAM-1 in control group was (22.63±3.40)ng/L. The above values were compared between any two groups, differences were statistically significant (all P < 0.01). The serum level of urea nitrogen in patients with HFRS in early stage, critical stage, convalescent stage were (5.16±0.12), (33.84±9.24),(8.20±1.30)mmol/L, respectively. The serum level of urea nitrogen in control group was (4.20±0.56)mmol/L.The above value were compared between any two groups, the differences were statistically significant (all P< 0.01). Conclusions sICAM-1 is involved in the pathogenesis of HFRS as protective factors. Cellular immune playes an important role in the pathogenesis of HFRS.