摘要目的：分析2012年青海省人间布鲁杆菌病（简称布病）疫情态势，为布病的防治工作提出建议。方法2012年在青海省选择平安县、海晏县、天峻县、达日县、久治县、河南县6个县开展布病调查，每个县选择3~4个乡为调查点，调查7~60岁与牲畜接触密切的重点人群。采用虎红平板凝集试验（RBPT）、试管凝集试验（SAT）和抗人球蛋白试验（Coombs）进行血清学检测，根据《布鲁氏菌病诊断标准》（WS 269-2007）进行诊断。结果6个县共计检查4253人， RBPT 阳性率为2.92%（124/4253），SAT 阳性率为0.85%（36/4253）， Coombs阳性率为0.05%（2/4253），确定感染人数124人，感染率为2.92%（124/4253），患病人数71人，患病率为1.67%（71/4253），发现新发病例68人。结论青海省局部地区人间布病疫情活跃，应加强对职业人群的教育，提升自我的防控能力，控制人间疫情的发生。

abstractsObjective Though analyzing the epidemiological trend of human Brucellosis in Qinghai Province in 2012, to provide a advice for Brucellosis prevention and control. Methods Brucellosis investigation was carried out on key populations aged 7-60 years who were keeping in touch with livestock in Ping’an County, Haiyan County, Tianjun County, Dari County, Jiuzhi County, Henan County, and three or four towns were selected as investigation sites in each county; then serological test was done with the methods of the rose bengal plate agglutination test(RBPT), standard tube agglutination test(SAT) and Coombs; diagnosis was based on “Diagnostic Criteria for Brucellosis”( WS 269-2007 ) . Results A total of 4 253 people in the 6 counties were investigated;the positive rate of RBPT was 2.92%(124/4 253); the positive rate of SAT was 0.85%(36/4 253), while the Coombs was 0.05%(2/4 253), totally infected people was 124, the infection rate was 2.92%(124/4 253); the number of patients was 71, the prevalence rate was 1.67%(71/4 253); and new cases were 68. Conclusions Prevalence of human Brucellosis in Qinghai Province is active in some local areas. We should strengthen health education of occupational population, improve people’s ability of prevention and control, and control prevalence of Human epidemic situation.