摘要目的：了解浙江省2003-2012年人间布鲁杆菌病（简称布病）的分布特征及流行规律。方法收集浙江省2003-2012年确诊布病病例的个案调查表、各市及监测点布病防治工作年报表等资料，对病例的人群分布，地区分布，感染来源及感染途径，病原学情况及临床症状、体征等进行描述性分析。结果2003-2012年浙江省共报告布病病例323例，年均发病率为0.070/10万，其中2012年发病率最高，为0.190/10万。在所报告的布病病例中，职业人群占84.21%（272/323），从事职业以畜产品收购、屠宰、贩运者居多，占65.02%（210/323）；非职业人群占15.79%（51/323）。布病发病地区的分布呈逐年扩散趋势，其中绍兴市年均发病率最高，为0.226/10万。通过接触羊感染占92.88%（300/323）；通过接触牛感染占7.12%（23/323）。287例布病急性期患者进行了血培养，其中检出羊种布鲁杆菌39株、牛种布鲁杆菌2株。对确诊的120例患者进行了布病慢性化调查，慢性化率为3.33%（4/120）。结论浙江省布病疫情有不断扩散趋势；传染源主要为北方输入性羊；发病人群主要为职业人群。应加强对重点地区职业人员的主动监测、健康教育和行为干预。

abstractsObjective To understand the epidemiological distribution and epidemic situation of brucellosis cases in Zhejiang Province in 2003 - 2012. Methods Questionnaires of confirmed brucellosis cases, annual reports of prevention and control work of brucellosis in the cities and monitoring points were collected and analyzed in 2003 - 2012. Population distribution, regional distribution, infection sources and routes of infection, aetiology and clinical symptoms and signs of the brucellosis cases were analyzed descriptively. Results A total of 323 brucellosis cases were reported in 2003 - 2012, the average annual incidence rate was 0.070/one hundred thousand, the incidence rate in 2012(0.190/one hundred thousand) was high. There were 272 people of the 323 brucellosis cases were from occupational populations, accounting for 84.21%(272/323); people worked in buying, slaughtering and trafficking of livestock products were majority of the cases, accounting for 65.02%(210/323); and unoccupational population was accounting for 15.79%(51/323). Regional distribution of brucellosis was gradually spreading; the average incidence rate of Shaoxing City was the highest ( 0 . 226/one hundred thousand ) . Three hundred patients were infected by sheep, accounting for 92.88%(300/323), and only 7.12%(23/323) of the patients were infected by cattle. Two hundred and eighty-seven acute phase patients of brucellosis were checked by blood culture, and thirty-nine Brucella melitensis strains and two Brucella abortus strains were detected. The chronicity survey of 120 confirmed cases of brucellosis were conducted, chronicity rate was 3.33%(4/120). Conclusions Trends in the epidemic situation of brucellosis in Zhejiang Province has continued to spread. The main source of infection is sheep from the North. Occupational populations are major populations at risk. The key of prevention and control is to strengthen the active monitoring of occupation personnel , health education and behavior intervention.