摘要目的 探讨饮水氟含量与儿童氟斑牙的剂量反应关系及其基准剂量(BMD),为修订《生活饮用水卫生标准》(GB 5749-2006)中水氟限值提供科学依据.方法 在江苏、山东、河北、安徽、河南、陕西6个省份抽取29个改水年限在5年及以上的调查村,采集一次性水样,氟离子选择电极法检测水氟含量,Dean法检查8～12岁儿童氟斑牙患病情况.采用单因素回归分析法测算地方性氟中毒病区饮水氟含量的临界值,基准剂量法测算饮水氟含量的BMD及其95％可信区间下限(BMDL).结果 29个调查村,饮水氟含量范围为0.41～2.85 mg/L;共调查3 043名8～ 12岁儿童,检出氟斑牙919名,检出率为30.2％.饮水氟含量与8～ 12岁儿童氟斑牙患病率的单因素回归方程为Y氟斑牙患病率=6.005 6+20.058 8X,并具有统计学意义(F=12.19,P＜0.01),基于该方程测算地方性氟中毒病区饮水氟含量的临界值为1.20 mg/L.经基准剂量法测算的BMD值为1.23 mg/L,BMDL值为0.89 mg/L.结论 饮水氟含量与儿童氟斑牙患病率之间存在显著相关.目前我国《生活饮用水卫生标准》(GB 5749-2006)规定的农村小型集中式供水和分散式供水水氟标准是合理的.

abstractsObjective To further explore the dose-response relationship between water fluoride content and denial fluorosis and the benchmark dose (BMD),to provide a scientific basis for revising the critical value of water fluoride of "Drinking Water Health Standards" (GB 5749-2006).Methods Totally 29 villages with over 5 years water improvement in Jiangsu,Shandong,Hebei,Anhui,Henan,and Shaanxi provinces were selected as survey sites.Disposable water samples were collected,fluoride ion selective electrode method was used for determination of water fluorine content;dental fluorosis was checked for children aged 8 to 12 years by Dean method.The critical value of water fluoride content was calculated using single factor regression analysis.BMD and it's 95％ confidence interval lower limit (BMDL) were measured by BMD method.Results In the 29 survey sites,the fluoride content in drinking water ranged from 0.41 to 2.85 mg/L;in 3 043 children aged 8 to 12 years,919 children with dental fluorosis were detected,the detection rate was 30.2％.The single factor regression equation was Y =6.005 6 + 20.058 8X between water fluoride content and dental fluorosis prevalence of children,which had statistical significance (F =12.19,P ＜ 0.01).The critical value of water fluoride content was 1.20 mg/L on account of the equation.BMD and BMDL were 1.23 and 0.89 mg/L,respectively.Conclusions There is a significant correlation between water fluorine content and children's dental fluorosis prevalence.Currently,the critical value of water fluoride of "Drinking Water Health Standards" (GB 5749-2006) is reasonable.