摘要目的 对比研究不同留尿方式对尿碘含量检测结果的影响,为个体化尿碘检测找到合适的留尿方式.方法 选择健康正常成年人20人,收集1d内的随意尿样、连续5d的24h尿样和晨尿,砷铈催化分光光度法检测尿碘.对上述3种留尿方式的尿碘检测结果进行变异系数(cV)分析,将随意尿和晨尿碘含量检测结果分别与24h尿样进行对比分析(配对t检验).结果 随意尿、晨尿和24 h尿样碘含量检测结果的CV范围分别为12.5％ ～ 57.4％、5.4％ ～ 26.0％和3.4％～16.6％,主要分布在30.39％、11.74％、7.91％附近.随意尿样碘含量检测结果与24 h尿样比较,差异有统计学意义(t=-4.231,P＜0.05),晨尿与24h尿样比较,差异有统计学意义(t=3.884,P＜0.05).结论 采集24 h尿样是最佳的个体化尿碘检测的尿液留取方式.

abstractsObjective By studying the variation of individual urinary iodine concentration due to different ways of urine sample collection to optimize it for standard clinical evaluation.Methods Totally 20 healthy adults were recruited and their urine samples were collected as a random urine sample within 1 day,the 24 hour urine and morning urine samples within 5 successive days,respectively.The coefficient of variation in each group was calculated.Paired t test was used to compare the results of 24 hour urine with the results of random urine and that of morning urine samples,respectively.Results The range of individual coefficient of variation for random urine sample within one day was 12.5％-57.4％,while most of the coefficients of variation were around 30.39％.In contrast,the individual coefficients of variation of morning urine sample and 24 hour urine results within 5 days were 5.4％-26.0％ and 3.4％-16.6％ and most of them were at about 11.74％ and 7.91％.The paired t test showed that the results of random urine sample were significantly different compared with that of 24 hour urine (t =-4.231,P ＜ 0.05).On the other hand,there was also significant difference for the results of morning urine compared with that of 24 hour urine (t =3.884,P ＜ 0.05).Conclusion This study suggests that 24 hour urine is the most appropriate way of sample collection for individualized detection of urinary iodine.