摘要A multicenter prospective epidemiological survey on the etiologic agents of invasive candidosis was conducted in Russia in the period of 2012-2014.Samples were collected from 284 patients with invasive candidosis and Candida species isolated by culture.The species were identified by DNA sequencing and MALDI-TOF massspectrometry.A total of 322 isolates were recovered,in which 96％ of Candida species belonged to six major species,namely,C albicans (43.2％),C.parapsilosis (20.2％),C.glabrata (11.5％),C.tropicalis (9.6％),C.krusei (6.2％),and C.guilliermondii (5.3％).Most Candida species were isolated from blood samples (83.23％).Notably,the prevalence rate of C.albicans reduced from 52.38％ to 32.79％ (2012 vs.2014) (P =0.01) whereas that of non-C.albicans increased from 47.62％ (2012) to 67.21％ (2014) (P ＜ 0.01).Species distribution differed among geographical regions;specifically,the prevalence rate of C.albicans as an etiologic agent of invasive candidosis in Siberian Federal region was significantly higher than that in other Federal regions.Results indicated a shift from C.albicans to non-C,albicans.Therefore,a detailed investigation on the contributing factors and appropriate treatment of invasive candidosis is needed.