摘要N6-methyladenosine(m6A)RNA modification has emerged as a pivotal epitranscriptomic mark shaping RNA metabolism and cellular programs.Among the diverse m6A reader proteins,YTHDF2 has garnered significant attention as a key regulator of RNA stability.Recent studies highlight the multifaceted roles of YTHDF2 in orchestrating hematopoietic stem cell self-renewal and differentiation,fine-tuning immune cell development and function,and modulating tumor-immune interactions within the tumor microenvironment.YTHDF2 has also been shown to function as a reader for RNA 5-methylcytosine(m5C)modification.By linking m6A-and/or m5C-dependent RNA dynamics to hemato-immune homeostasis,YTHDF2 functions as a central epitranscriptomic integrator linking intrinsic genetic programs to developmental and environmental cues.Here,we summarize current advances in understanding YTHDF2-mediated RNA regulation across physiological and pathological contexts,discuss its potential as a therapeutic target in immune-related diseases and cancers,and highlight future directions in the field.