换一批摘要The MBOAT enzyme family, identified in 2000, comprises 11 genes in the human genome that participate in a variety of biological processes. MBOAT enzymes contain multiple transmembrane domains and share two active site residues, histidine and asparagine. Several MBOAT members are drug targets for major human diseases, including atherosclerosis, obesity, AIzheimer disease, and viral infections. Here we review the historical aspects of MBOAT enzymes, classify them biochemically into 3 subgroups, and describe the essential features of each member.
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关键词
cholesterol metabolismneutral lipid biosynthesisprotein acylationmembrane phospholipid remodelingatherosclerosisdiabetesobesitycancernutrient sensing
分类号
K826.15
栏目名称
DOI
10.1007/s11515-011-1149-z
发布时间
2011-09-22（万方平台首次上网日期，不代表论文的发表时间）
基金项目
US NIH（(HL60306;AG37609)）
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