摘要目的 探讨诱导化疗加超分割放疗治疗鼻咽癌的疗效和并发症情况.方法 2000年1月至2002年11月来院首诊的101例鼻咽癌患者,采用诱导化疗加超分割放疗治疗,化疗采用CF方案,放疗采用60Co-y线外照射,1.2 Gy/次,2次/d,5d/周,间隔≥6 h,全疗程鼻咽中位放疗剂量7 255 eGy,颈部中位放疗剂量7 201 cGy.结果 放疗过程中黏膜反应≥3级的病例占24.8%,放化疗结束时完全缓解率为83.2%,1年生存率为90.1%,2年生存率82.2%,5年生存率为57.4%.结论 诱导化疗加超分割放疗患者能耐受,疗效好,为鼻咽癌患者提供了一种可能有效的治疗选择,其确切疗效有待大规模临床试验验证.

abstractsObjective To approach the therapeutic effects and complication of combined induction chemo-therapy and hyperfraetionated radiotherapy for nasopharyngeal carcinoma.Methods Form January 2000 to November 2002,101 patients with nasopharyngeal carcinoma were treated by combined induction chemotherapy and hyperfrac-tionated radiotherapy.For hyperfraetionated radiotherapy,y-ray from 60 Co were performed and two daily fractions of 1.2Gy were given,with an interval of≥6 hours,5 days per week to a median dose of 7255cGy for nasopharynx and 7201cGy for neck.For induction chemotherapy,carboplatin and 5-fluorouraeil were transfused.Results The inci-denee rate of greater than or equal to the third grade acute mucositis was 24.8%.The complete remission rate after treatment was 83.2%.The 1,2 and 5 year survival rate was 90.1%,82.2%-and 57.4%.Conclusion With this treatment schedule,patient's tolerance and therapeutic effect is good.It provids a treatment means for nasopharyngeal carcinoma.But it must be validated by the large-scale clinical trials.